BRD-A13122391_16-HYDROXYTRIPTOLIDE_PC3_24.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

390 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_PC3_24.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRL4 adhesion G protein-coupled receptor L4
AIF1 allograft inflammatory factor 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOB aldolase B, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
ATF3 activating transcription factor 3
ATP10D ATPase, class V, type 10D
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BCAP31 B-cell receptor-associated protein 31
BCHE butyrylcholinesterase
BEX4 brain expressed, X-linked 4
BGN biglycan
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
C9ORF16 chromosome 9 open reading frame 16
CA11 carbonic anhydrase XI
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALCRL calcitonin receptor-like
CALD1 caldesmon 1
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CD200 CD200 molecule
CD24 CD24 molecule
CD38 CD38 molecule
CD8A CD8a molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRELD2 cysteine-rich with EGF-like domains 2
CRIP2 cysteine-rich protein 2
CTSO cathepsin O
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DACH1 dachshund family transcription factor 1
DCN decorin
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DEFA4 defensin, alpha 4, corticostatin
DMPK dystrophia myotonica-protein kinase
DPYSL3 dihydropyrimidinase-like 3
EDNRA endothelin receptor type A
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESR1 estrogen receptor 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD6 frizzled class receptor 6
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GIMAP6 GTPase, IMAP family member 6
GJA1 gap junction protein, alpha 1, 43kDa
GLT8D2 glycosyltransferase 8 domain containing 2
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
GUK1 guanylate kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HPSE heparanase
HSBP1 heat shock factor binding protein 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITM2B integral membrane protein 2B
ITM2C integral membrane protein 2C
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KRT8 keratin 8, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP5 lysosomal-associated membrane protein family, member 5
LDOC1 leucine zipper, down-regulated in cancer 1
LGMN legumain
LYPD1 LY6/PLAUR domain containing 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MMP10 matrix metallopeptidase 10
MN1 meningioma (disrupted in balanced translocation) 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MT1E metallothionein 1E
MXI1 MAX interactor 1, dimerization protein
NOX4 NADPH oxidase 4
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB1 nucleobindin 1
NXN nucleoredoxin
OSBPL10 oxysterol binding protein-like 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAWR PRKC, apoptosis, WT1, regulator
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLD3 phospholipase D family, member 3
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRAF2 PRA1 domain family, member 2
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
PSENEN presenilin enhancer gamma secretase subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBBP6 retinoblastoma binding protein 6
RBP1 retinol binding protein 1, cellular
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RNF11 ring finger protein 11
RSRP1 arginine/serine-rich protein 1
RUNX3 runt-related transcription factor 3
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC3 syndecan 3
SERINC1 serine incorporator 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SIRPA signal-regulatory protein alpha
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORT1 sortilin 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STON1 stonin 1
SULF1 sulfatase 1
TAGLN transgelin
TCEA2 transcription elongation factor A (SII), 2
TDO2 tryptophan 2,3-dioxygenase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS3 thrombospondin 3
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
TUSC3 tumor suppressor candidate 3
VAMP3 vesicle-associated membrane protein 3
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
VWA5A von Willebrand factor A domain containing 5A
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC11 zinc finger, DHHC-type containing 11
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADA adenosine deaminase
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA7 annexin A7
ASPH aspartate beta-hydroxylase
B3GNT1
BCL2A1 BCL2-related protein A1
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C2CD5 C2 calcium-dependent domain containing 5
C7ORF49 chromosome 7 open reading frame 49
CASC3 cancer susceptibility candidate 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CFD complement factor D (adipsin)
CHD7 chromodomain helicase DNA binding protein 7
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSK c-src tyrosine kinase
CXCL8 chemokine (C-X-C motif) ligand 8
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
ECD ecdysoneless homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ELAVL1 ELAV like RNA binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GMDS GDP-mannose 4,6-dehydratase
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTPBP8 GTP-binding protein 8 (putative)
HAS2 hyaluronan synthase 2
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA8 heat shock 70kDa protein 8
ICAM2 intercellular adhesion molecule 2
IGFBP1 insulin-like growth factor binding protein 1
IGHD immunoglobulin heavy constant delta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
ISG20 interferon stimulated exonuclease gene 20kDa
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
KRT15 keratin 15, type I
LAMB3 laminin, beta 3
LPAR1 lysophosphatidic acid receptor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP1B microtubule-associated protein 1B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MATN2 matrilin 2
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MED1 mediator complex subunit 1
MED24 mediator complex subunit 24
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MRPS35 mitochondrial ribosomal protein S35
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NOTCH2NL notch 2 N-terminal like
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP85 nucleoporin 85kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAIP1 poly(A) binding protein interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PITX1 paired-like homeodomain 1
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PRRC2C proline-rich coiled-coil 2C
PSD3 pleckstrin and Sec7 domain containing 3
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
PWP1 PWP1 homolog (S. cerevisiae)
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAB2A RAB2A, member RAS oncogene family
RANGRF RAN guanine nucleotide release factor
RBBP4 retinoblastoma binding protein 4
RBP4 retinol binding protein 4, plasma
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF5 serine/arginine-rich splicing factor 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SVIL supervillin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMPO thymopoietin
TNNC1 troponin C type 1 (slow)
TPX2 TPX2, microtubule-associated
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB4B tubulin, beta 4B class IVb
UBE3B ubiquitin protein ligase E3B
UCK2 uridine-cytidine kinase 2
ZIC1 Zic family member 1