BRD-A13122391_16-HYDROXYTRIPTOLIDE_OV7_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

131 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_OV7_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
ARL3 ADP-ribosylation factor-like 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN10 claudin 10
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FLRT2 fibronectin leucine rich transmembrane protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLT1B golgi transport 1B
GPM6A glycoprotein M6A
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HTRA1 HtrA serine peptidase 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MN1 meningioma (disrupted in balanced translocation) 1
MX1 MX dynamin-like GTPase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
THBS1 thrombospondin 1
TNIP1 TNFAIP3 interacting protein 1
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
CHERP calcium homeostasis endoplasmic reticulum protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
HK1 hexokinase 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
KEAP1 kelch-like ECH-associated protein 1
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
TARP TCR gamma alternate reading frame protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDAC1 voltage-dependent anion channel 1
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2