BRD-A13122391_16-HYDROXYTRIPTOLIDE_NCIH596_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

171 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_NCIH596_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
AEBP1 AE binding protein 1
AREG amphiregulin
ASPN asporin
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
C1QTNF3 C1q and tumor necrosis factor related protein 3
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CERS6 ceramide synthase 6
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CTSV cathepsin V
DCN decorin
DGKA diacylglycerol kinase, alpha 80kDa
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
FAM69A family with sequence similarity 69, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
GAS6 growth arrest-specific 6
GM2A GM2 ganglioside activator
GPX3 glutathione peroxidase 3
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
JAM3 junctional adhesion molecule 3
KRT20 keratin 20, type I
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
LRRN3 leucine rich repeat neuronal 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1D myosin ID
NTS neurotensin
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR2 phosphatase and actin regulator 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PNKP polynucleotide kinase 3'-phosphatase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RNASE6 ribonuclease, RNase A family, k6
RSAD2 radical S-adenosyl methionine domain containing 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT6 septin 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SRPX sushi-repeat containing protein, X-linked
TECR trans-2,3-enoyl-CoA reductase
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADM adrenomedullin
AIM2 absent in melanoma 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARID4B AT rich interactive domain 4B (RBP1-like)
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FRMD4A FERM domain containing 4A
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KYNU kynureninase
LAT2 linker for activation of T cells family, member 2
LHX2 LIM homeobox 2
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MET MET proto-oncogene, receptor tyrosine kinase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PCBP2 poly(rC) binding protein 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
RAP2B RAP2B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLBP stem-loop binding protein
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TNS3 tensin 3
TOB2 transducer of ERBB2, 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
WEE1 WEE1 G2 checkpoint kinase