BRD-A13122391_16-HYDROXYTRIPTOLIDE_NCIH2073_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_NCIH2073_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AIDA axin interactor, dorsalization associated
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
ASS1 argininosuccinate synthase 1
C1ORF54 chromosome 1 open reading frame 54
CD24 CD24 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CKLF chemokine-like factor
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
DCAF10 DDB1 and CUL4 associated factor 10
DDR1 discoidin domain receptor tyrosine kinase 1
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
EDNRA endothelin receptor type A
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ELN elastin
EMP1 epithelial membrane protein 1
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FST follistatin
GAS1 growth arrest-specific 1
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
LAGE3 L antigen family, member 3
LAMB2 laminin, beta 2 (laminin S)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED2 melanoma antigen family D2
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NMU neuromedin U
PBX3 pre-B-cell leukemia homeobox 3
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
PSENEN presenilin enhancer gamma secretase subunit
PSPH phosphoserine phosphatase
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SCARB2 scavenger receptor class B, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SET SET nuclear proto-oncogene
SFRP4 secreted frizzled-related protein 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VNN1 vanin 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CRYM crystallin, mu
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
MLPH melanophilin
MMP7 matrix metallopeptidase 7
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRG1 neuregulin 1
NUDCD3 NudC domain containing 3
PCDH9 protocadherin 9
PDE4D phosphodiesterase 4D, cAMP-specific
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PTCH1 patched 1
RAD51C RAD51 paralog C
RBM38 RNA binding motif protein 38
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFN stratifin
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TP63 tumor protein p63
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B
ZFP36L1 ZFP36 ring finger protein-like 1