BRD-A13122391_16-HYDROXYTRIPTOLIDE_MDST8_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_MDST8_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
CALML5 calmodulin-like 5
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CRAT carnitine O-acetyltransferase
CREB3L2 cAMP responsive element binding protein 3-like 2
CST6 cystatin E/M
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
DEFB1 defensin, beta 1
E2F2 E2F transcription factor 2
EFHD1 EF-hand domain family, member D1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBN1 fibrillin 1
GREM1 gremlin 1, DAN family BMP antagonist
GTF3A general transcription factor IIIA
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HOPX HOP homeobox
HOXA10 homeobox A10
IDE insulin-degrading enzyme
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP5F inositol polyphosphate-5-phosphatase F
ITM2C integral membrane protein 2C
JAG1 jagged 1
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TMED2 transmembrane emp24 domain trafficking protein 2
TPD52 tumor protein D52
UBQLN2 ubiquilin 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD5 C2 calcium-dependent domain containing 5
CASC3 cancer susceptibility candidate 3
CCL2 chemokine (C-C motif) ligand 2
CFI complement factor I
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KIAA0355 KIAA0355
KLF2 Kruppel-like factor 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PNN pinin, desmosome associated protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
RBM7 RNA binding motif protein 7
RHOB ras homolog family member B
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
TNF tumor necrosis factor
TSC22D1 TSC22 domain family, member 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2