BRD-A13122391_16-HYDROXYTRIPTOLIDE_MCF7_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

271 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_MCF7_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ADAM9 ADAM metallopeptidase domain 9
ADAMTSL3 ADAMTS-like 3
AIDA axin interactor, dorsalization associated
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMT aminomethyltransferase
ANOS1 anosmin 1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CAPN2 calpain 2, (m/II) large subunit
CAV2 caveolin 2
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CES2 carboxylesterase 2
CHN2 chimerin 2
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CNPY3 canopy FGF signaling regulator 3
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DGKA diacylglycerol kinase, alpha 80kDa
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX2 epoxide hydrolase 2, cytoplasmic
EXPH5 exophilin 5
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FOXF1 forkhead box F1
GAS6 growth arrest-specific 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6A glycoprotein M6A
GSDMB gasdermin B
GSN gelsolin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
NDRG1 N-myc downstream regulated 1
NEB nebulin
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NES nestin
NMU neuromedin U
NPTX2 neuronal pentraxin II
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD6 programmed cell death 6
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLEK2 pleckstrin 2
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SEPT10 septin 10
SEPT2 septin 2
SPAG16 sperm associated antigen 16
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STEAP1 six transmembrane epithelial antigen of the prostate 1
STON1 stonin 1
TAGLN transgelin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
USP9Y ubiquitin specific peptidase 9, Y-linked
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VWA1 von Willebrand factor A domain containing 1
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF83 zinc finger protein 83
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADNP activity-dependent neuroprotector homeobox
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
B3GNT1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL3 B-cell CLL/lymphoma 3
BCL7B B-cell CLL/lymphoma 7B
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CXCL14 chemokine (C-X-C motif) ligand 14
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA1 ephrin-A1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
FADD Fas (TNFRSF6)-associated via death domain
FAM208B family with sequence similarity 208, member B
FAM222B family with sequence similarity 222, member B
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
INSIG1 insulin induced gene 1
IRX5 iroquois homeobox 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIAA1324 KIAA1324
KLF10 Kruppel-like factor 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KYNU kynureninase
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH9 protocadherin 9
PDGFRL platelet-derived growth factor receptor-like
PDS5B PDS5 cohesin associated factor B
PER2 period circadian clock 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPIF peptidylprolyl isomerase F
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOB ras homolog family member B
RNF111 ring finger protein 111
RPL27A ribosomal protein L27a
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SEC24A SEC24 family member A
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TMEM70 transmembrane protein 70
TNC tenascin C
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
VEZF1 vascular endothelial zinc finger 1
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZCCHC2 zinc finger, CCHC domain containing 2
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267
ZNF410 zinc finger protein 410