BRD-A13122391_16-HYDROXYTRIPTOLIDE_LOVO_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_LOVO_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADM1 cell adhesion molecule 1
CBX1 chromobox homolog 1
CD24 CD24 molecule
CLDN10 claudin 10
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A2 collagen, type IV, alpha 2
COMP cartilage oligomeric matrix protein
CRELD2 cysteine-rich with EGF-like domains 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTSZ cathepsin Z
DAPK1 death-associated protein kinase 1
ECHDC3 enoyl CoA hydratase domain containing 3
EID1 EP300 interacting inhibitor of differentiation 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
HIST1H2BK histone cluster 1, H2bk
HOXB5 homeobox B5
HOXB6 homeobox B6
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLK5 kallikrein-related peptidase 5
LAMP3 lysosomal-associated membrane protein 3
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MSN moesin
MT1E metallothionein 1E
MT1G metallothionein 1G
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NID2 nidogen 2 (osteonidogen)
NLRP2 NLR family, pyrin domain containing 2
PAX8 paired box 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PROSC proline synthetase co-transcribed homolog (bacterial)
PSENEN presenilin enhancer gamma secretase subunit
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RPA3 replication protein A3, 14kDa
RSAD2 radical S-adenosyl methionine domain containing 2
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SNX11 sorting nexin 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TUBB2B tubulin, beta 2B class IIb
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF264 zinc finger protein 264
ZNF532 zinc finger protein 532
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD7 chromodomain helicase DNA binding protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKAP4 cytoskeleton-associated protein 4
CNPY3 canopy FGF signaling regulator 3
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA4 ephrin-A4
EIF4A1 eukaryotic translation initiation factor 4A1
ENAH enabled homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
FAM46C family with sequence similarity 46, member C
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HAS2 hyaluronan synthase 2
HRH1 histamine receptor H1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL20RA interleukin 20 receptor, alpha
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
LDLR low density lipoprotein receptor
LTF lactotransferrin
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MED21 mediator complex subunit 21
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NACA nascent polypeptide-associated complex alpha subunit
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PITX1 paired-like homeodomain 1
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNN pinin, desmosome associated protein
POU2AF1 POU class 2 associating factor 1
PRR7 proline rich 7 (synaptic)
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REXO2 RNA exonuclease 2
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RPL37A ribosomal protein L37a
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
STK17A serine/threonine kinase 17a
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
THUMPD1 THUMP domain containing 1
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
TSC22D2 TSC22 domain family, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBAP2L ubiquitin associated protein 2-like
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZMYND8 zinc finger, MYND-type containing 8