BRD-A13122391_16-HYDROXYTRIPTOLIDE_JHUEM2_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_JHUEM2_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CCNA1 cyclin A1
CD44 CD44 molecule (Indian blood group)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLIC4 chloride intracellular channel 4
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
EPAS1 endothelial PAS domain protein 1
ETHE1 ethylmalonic encephalopathy 1
FKBP1A FK506 binding protein 1A, 12kDa
FXYD3 FXYD domain containing ion transport regulator 3
GPM6A glycoprotein M6A
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAG1 jagged 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NXT2 nuclear transport factor 2-like export factor 2
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PBX1 pre-B-cell leukemia homeobox 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PNMA2 paraneoplastic Ma antigen 2
PRSS21 protease, serine, 21 (testisin)
RAB31 RAB31, member RAS oncogene family
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT2 septin 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOX11 SRY (sex determining region Y)-box 11
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRDV3 T cell receptor delta variable 3
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
BAMBI BMP and activin membrane-bound inhibitor
BRD3 bromodomain containing 3
CA2 carbonic anhydrase II
CCNF cyclin F
CCNJ cyclin J
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GSTM3 glutathione S-transferase mu 3 (brain)
HAUS3 HAUS augmin-like complex, subunit 3
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KLF10 Kruppel-like factor 10
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MED17 mediator complex subunit 17
MEGF9 multiple EGF-like-domains 9
MICALL1 MICAL-like 1
MRPS2 mitochondrial ribosomal protein S2
MTERF3 mitochondrial transcription termination factor 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OXTR oxytocin receptor
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PRPF4B pre-mRNA processing factor 4B
PTDSS1 phosphatidylserine synthase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM7 RNA binding motif protein 7
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
SERTAD2 SERTA domain containing 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SON SON DNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLE4 transducin-like enhancer of split 4
TLR4 toll-like receptor 4
TMEM185B transmembrane protein 185B
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB11 zinc finger and BTB domain containing 11
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF586 zinc finger protein 586