BRD-A13122391_16-HYDROXYTRIPTOLIDE_HT115_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_HT115_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ATMIN ATM interactor
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CDK19 cyclin-dependent kinase 19
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DFNA5 deafness, autosomal dominant 5
DYNLT1 dynein, light chain, Tctex-type 1
ECM1 extracellular matrix protein 1
GAGE3 G antigen 3
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HOOK2 hook microtubule-tethering protein 2
HOPX HOP homeobox
IPO13 importin 13
ITGA7 integrin, alpha 7
KDM5B lysine (K)-specific demethylase 5B
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
NDRG2 NDRG family member 2
PMEL premelanosome protein
PRAME preferentially expressed antigen in melanoma
PRUNE2 prune homolog 2 (Drosophila)
S100A7 S100 calcium binding protein A7
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A1 solute carrier family 38, member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
VIM vimentin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
C8ORF4 chromosome 8 open reading frame 4
CD163 CD163 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COPS7A COP9 signalosome subunit 7A
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
FLRT3 fibronectin leucine rich transmembrane protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GCA grancalcin, EF-hand calcium binding protein
GLUL glutamate-ammonia ligase
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF10 Kruppel-like factor 10
KRT19 keratin 19, type I
LTBP1 latent transforming growth factor beta binding protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MEGF9 multiple EGF-like-domains 9
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOTCH1 notch 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFC platelet derived growth factor C
PGD phosphogluconate dehydrogenase
PLK1 polo-like kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTX3 pentraxin 3, long
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SDPR serum deprivation response
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SYBU syntabulin (syntaxin-interacting)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2