BRD-A13122391_16-HYDROXYTRIPTOLIDE_HEPG2_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_HEPG2_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
C3ORF14 chromosome 3 open reading frame 14
CECR1 cat eye syndrome chromosome region, candidate 1
CEP70 centrosomal protein 70kDa
CFB complement factor B
CHODL chondrolectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
EXPH5 exophilin 5
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDOC1 leucine zipper, down-regulated in cancer 1
MAMLD1 mastermind-like domain containing 1
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NREP neuronal regeneration related protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP1 retinol binding protein 1, cellular
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53I3 tumor protein p53 inducible protein 3
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ARF6 ADP-ribosylation factor 6
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EHD1 EH-domain containing 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GCH1 GTP cyclohydrolase 1
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KLF10 Kruppel-like factor 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNMA1 paraneoplastic Ma antigen 1
POU2AF1 POU class 2 associating factor 1
PPIF peptidylprolyl isomerase F
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RBM39 RNA binding motif protein 39
RHOB ras homolog family member B
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SCAF8 SR-related CTD-associated factor 8
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD7 SMAD family member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF2 serine/arginine-rich splicing factor 2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
XBP1 X-box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB1 zinc finger and BTB domain containing 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF281 zinc finger protein 281
ZNF410 zinc finger protein 410