BRD-A13122391_16-HYDROXYTRIPTOLIDE_HCT116_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

181 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_HCT116_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BSPRY B-box and SPRY domain containing
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CERK ceramide kinase
CHIC2 cysteine-rich hydrophobic domain 2
CKB creatine kinase, brain
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F2R coagulation factor II (thrombin) receptor
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HP haptoglobin
IFITM1 interferon induced transmembrane protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
KDM4B lysine (K)-specific demethylase 4B
LEF1 lymphoid enhancer-binding factor 1
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1 PDZ domain containing 1
PNPLA4 patatin-like phospholipase domain containing 4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SORD sorbitol dehydrogenase
SORT1 sortilin 1
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
UGDH UDP-glucose 6-dehydrogenase
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATF3 activating transcription factor 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FAM13A family with sequence similarity 13, member A
FAM208B family with sequence similarity 208, member B
FBL fibrillarin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB7 homeobox B7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MELK maternal embryonic leucine zipper kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NVL nuclear VCP-like
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
RPL10 ribosomal protein L10
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2 ribonucleotide reductase M2
SAMD4A sterile alpha motif domain containing 4A
SAP30 Sin3A-associated protein, 30kDa
SDC1 syndecan 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPRY2 sprouty homolog 2 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCERG1 transcription elongation regulator 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXLNA taxilin alpha
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE2C ubiquitin-conjugating enzyme E2C
VCPKMT valosin containing protein lysine (K) methyltransferase
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF395 zinc finger protein 395