BRD-A13122391_16-HYDROXYTRIPTOLIDE_HCC515_24.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

238 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_HCC515_24.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPTL2 angiopoietin-like 2
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
ATF3 activating transcription factor 3
ATP10D ATPase, class V, type 10D
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BHMT2 betaine--homocysteine S-methyltransferase 2
BLNK B-cell linker
BSG basigin (Ok blood group)
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLIC5 chloride intracellular channel 5
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CTSA cathepsin A
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
DMPK dystrophia myotonica-protein kinase
ECM1 extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GM2A GM2 ganglioside activator
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMGN5 high mobility group nucleosome binding domain 5
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LINC00342 long intergenic non-protein coding RNA 342
LSR lipolysis stimulated lipoprotein receptor
LST1 leukocyte specific transcript 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
MICB MHC class I polypeptide-related sequence B
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOX4 NADPH oxidase 4
OSBPL10 oxysterol binding protein-like 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
PSENEN presenilin enhancer gamma secretase subunit
PTTG1IP pituitary tumor-transforming 1 interacting protein
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC3 syndecan 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SNN stannin
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM59 transmembrane protein 59
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TSPAN12 tetraspanin 12
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
BLMH bleomycin hydrolase
C2CD5 C2 calcium-dependent domain containing 5
C4BPA complement component 4 binding protein, alpha
C7 complement component 7
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CDC45 cell division cycle 45
CNOT7 CCR4-NOT transcription complex, subunit 7
COL4A5 collagen, type IV, alpha 5
COX11 COX11 cytochrome c oxidase copper chaperone
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLK1 delta-like 1 homolog (Drosophila)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HMGA1 high mobility group AT-hook 1
HSPA8 heat shock 70kDa protein 8
IARS isoleucyl-tRNA synthetase
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
KPNB1 karyopherin (importin) beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM3 minichromosome maintenance complex component 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MINA MYC induced nuclear antigen
MRPL12 mitochondrial ribosomal protein L12
MRPL19 mitochondrial ribosomal protein L19
MRPS35 mitochondrial ribosomal protein S35
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NAP1L1 nucleosome assembly protein 1-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSD3 pleckstrin and Sec7 domain containing 3
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
SVIL supervillin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D4 TBC1 domain family, member 4
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
UCK2 uridine-cytidine kinase 2
VAV3 vav 3 guanine nucleotide exchange factor