BRD-A13122391_16-HYDROXYTRIPTOLIDE_H1299_6.0_h_0.0799999982119_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_H1299_6.0_h_0.0799999982119_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
AIF1 allograft inflammatory factor 1
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
ASS1 argininosuccinate synthase 1
BACE2 beta-site APP-cleaving enzyme 2
BPHL biphenyl hydrolase-like (serine hydrolase)
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
C1ORF54 chromosome 1 open reading frame 54
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFI complement factor I
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IL17RB interleukin 17 receptor B
KCTD12 potassium channel tetramerization domain containing 12
LTBP1 latent transforming growth factor beta binding protein 1
MECOM MDS1 and EVI1 complex locus
MRPL13 mitochondrial ribosomal protein L13
MSMB microseminoprotein, beta-
MTUS1 microtubule associated tumor suppressor 1
MYCBP MYC binding protein
MYO1B myosin IB
NCF4 neutrophil cytosolic factor 4, 40kDa
NR2F1 nuclear receptor subfamily 2, group F, member 1
OSBPL1A oxysterol binding protein-like 1A
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPB surfactant protein B
SNX13 sorting nexin 13
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TESC tescalcin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIL TLR4 interactor with leucine-rich repeats
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
VSIG4 V-set and immunoglobulin domain containing 4
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
CAST calpastatin
CCNF cyclin F
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CNPY3 canopy FGF signaling regulator 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EGR3 early growth response 3
EGR4 early growth response 4
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
KLF10 Kruppel-like factor 10
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LEFTY1 left-right determination factor 1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G15 phospholipase A2, group XV
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PROM1 prominin 1
PURA purine-rich element binding protein A
PVRL3 poliovirus receptor-related 3
RAP2B RAP2B, member of RAS oncogene family
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A6 S100 calcium binding protein A6
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC38A2 solute carrier family 38, member 2
SPATA2 spermatogenesis associated 2
TAC1 tachykinin, precursor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF131 zinc finger protein 131
ZNF586 zinc finger protein 586