BRD-A13122391_16-HYDROXYTRIPTOLIDE_EFO27_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_EFO27_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AK1 adenylate kinase 1
BCAP31 B-cell receptor-associated protein 31
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CD93 CD93 molecule
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CST6 cystatin E/M
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
GPM6A glycoprotein M6A
GPR183 G protein-coupled receptor 183
GPX1 glutathione peroxidase 1
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
LPPR4 lipid phosphate phosphatase-related protein type 4
LST1 leukocyte specific transcript 1
MDFIC MyoD family inhibitor domain containing
MGP matrix Gla protein
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
OLFM1 olfactomedin 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TCF4 transcription factor 4
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VCAN versican
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BPIFA1 BPI fold containing family A, member 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EPCAM epithelial cell adhesion molecule
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
IGHD immunoglobulin heavy constant delta
INPP1 inositol polyphosphate-1-phosphatase
IPO13 importin 13
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NUP153 nucleoporin 153kDa
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
RAP2B RAP2B, member of RAS oncogene family
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC38A2 solute carrier family 38, member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TCERG1 transcription elongation regulator 1
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TP53BP2 tumor protein p53 binding protein 2
TRIM2 tripartite motif containing 2
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
VLDLR very low density lipoprotein receptor
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF318 zinc finger protein 318