BRD-A13122391_16-HYDROXYTRIPTOLIDE_DV90_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_DV90_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ADD3 adducin 3 (gamma)
ANOS1 anosmin 1
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
CDC42 cell division cycle 42
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSZ cathepsin Z
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHDDS dehydrodolichyl diphosphate synthase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DOK5 docking protein 5
E2F2 E2F transcription factor 2
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EMP1 epithelial membrane protein 1
EZR ezrin
FAP fibroblast activation protein, alpha
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
FSD1 fibronectin type III and SPRY domain containing 1
FST follistatin
GAS1 growth arrest-specific 1
HIP1 huntingtin interacting protein 1
HIRA histone cell cycle regulator
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM3 intercellular adhesion molecule 3
IFT57 intraflagellar transport 57
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MDFIC MyoD family inhibitor domain containing
MME membrane metallo-endopeptidase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSMB microseminoprotein, beta-
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NQO2 NAD(P)H dehydrogenase, quinone 2
PDE8B phosphodiesterase 8B
PDGFRL platelet-derived growth factor receptor-like
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPL periplakin
PRKD3 protein kinase D3
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
RGS5 regulator of G-protein signaling 5
SGK1 serum/glucocorticoid regulated kinase 1
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TOPBP1 topoisomerase (DNA) II binding protein 1
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CALML5 calmodulin-like 5
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB3 EPH receptor B3
F12 coagulation factor XII (Hageman factor)
FKBP11 FK506 binding protein 11, 19 kDa
FOXA2 forkhead box A2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
JMJD6 jumonji domain containing 6
KIAA1033 KIAA1033
LTF lactotransferrin
MID1IP1 MID1 interacting protein 1
MLPH melanophilin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP62 nucleoporin 62kDa
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POU2AF1 POU class 2 associating factor 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
STK10 serine/threonine kinase 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
XBP1 X-box binding protein 1