BRD-A13122391_16-HYDROXYTRIPTOLIDE_COV644_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_COV644_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AIM1 absent in melanoma 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD11 ankyrin repeat domain 11
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAX BCL2-associated X protein
BGN biglycan
CA1 carbonic anhydrase I
CA4 carbonic anhydrase IV
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CELF2 CUGBP, Elav-like family member 2
CEP57 centrosomal protein 57kDa
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DHDDS dehydrodolichyl diphosphate synthase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
ENO1 enolase 1, (alpha)
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FST follistatin
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
LHX2 LIM homeobox 2
LYPD1 LY6/PLAUR domain containing 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXRA5 matrix-remodelling associated 5
MZB1 marginal zone B and B1 cell-specific protein
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAX6 paired box 6
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PNPLA4 patatin-like phospholipase domain containing 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCI protein kinase C, iota
PRTN3 proteinase 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SEPT2 septin 2
SIRT3 sirtuin 3
SOX11 SRY (sex determining region Y)-box 11
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TPMT thiopurine S-methyltransferase
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TSPAN12 tetraspanin 12
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COCH cochlin
CTSB cathepsin B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FHL2 four and a half LIM domains 2
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
ITFG1 integrin alpha FG-GAP repeat containing 1
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KIN Kin17 DNA and RNA binding protein
KRT15 keratin 15, type I
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MKI67 marker of proliferation Ki-67
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
NRN1 neuritin 1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
OAT ornithine aminotransferase
PER2 period circadian clock 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PRKD3 protein kinase D3
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTER phosphotriesterase related
QPCT glutaminyl-peptide cyclotransferase
RAB25 RAB25, member RAS oncogene family
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAF8 SR-related CTD-associated factor 8
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
STC2 stanniocalcin 2
STX3 syntaxin 3
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WIPF2 WAS/WASL interacting protein family, member 2
ZEB2 zinc finger E-box binding homeobox 2