BRD-A13122391_16-HYDROXYTRIPTOLIDE_CORL23_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_CORL23_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ACSL5 acyl-CoA synthetase long-chain family member 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BST2 bone marrow stromal cell antigen 2
C1ORF115 chromosome 1 open reading frame 115
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFB complement factor B
CLCA4 chloride channel accessory 4
CLDN10 claudin 10
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CXADR coxsackie virus and adenovirus receptor
DEFB1 defensin, beta 1
EDN3 endothelin 3
EPCAM epithelial cell adhesion molecule
ERLIN2 ER lipid raft associated 2
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
GOLGA8H golgin A8 family, member H
H3F3B H3 histone, family 3B (H3.3B)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIST1H1C histone cluster 1, H1c
IFITM1 interferon induced transmembrane protein 1
KLHL9 kelch-like family member 9
LXN latexin
MAOA monoamine oxidase A
MID1 midline 1
MXRA5 matrix-remodelling associated 5
NES nestin
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE9A phosphodiesterase 9A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PEG3 paternally expressed 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PILRB paired immunoglobin-like type 2 receptor beta
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLVAP plasmalemma vesicle associated protein
PMEL premelanosome protein
PPAP2B phosphatidic acid phosphatase type 2B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM6 RNA binding motif protein 6
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RRBP1 ribosome binding protein 1
SCD5 stearoyl-CoA desaturase 5
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TRAF5 TNF receptor-associated factor 5
TSPAN6 tetraspanin 6
TST thiosulfate sulfurtransferase (rhodanese)
TYRP1 tyrosinase-related protein 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
C4BPA complement component 4 binding protein, alpha
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CANT1 calcium activated nucleotidase 1
CASD1 CAS1 domain containing 1
CCNF cyclin F
CCR2 chemokine (C-C motif) receptor 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK4 dedicator of cytokinesis 4
DPYSL2 dihydropyrimidinase-like 2
DSE dermatan sulfate epimerase
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
FST follistatin
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT14 keratin 14, type I
KRT19 keratin 19, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDNF neuron-derived neurotrophic factor
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PERP PERP, TP53 apoptosis effector
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTX3 pentraxin 3, long
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SMAGP small cell adhesion glycoprotein
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
STK17A serine/threonine kinase 17a
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM243 transmembrane protein 243, mitochondrial
TOB2 transducer of ERBB2, 2
TOR1A torsin family 1, member A (torsin A)
UFM1 ubiquitin-fold modifier 1
ZNF207 zinc finger protein 207