BRD-A13122391_16-HYDROXYTRIPTOLIDE_A673_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_A673_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ADK adenosine kinase
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASS1 argininosuccinate synthase 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DHCR24 24-dehydrocholesterol reductase
ECM1 extracellular matrix protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
IFI27 interferon, alpha-inducible protein 27
ITGB1BP1 integrin beta 1 binding protein 1
KIF5C kinesin family member 5C
KRT19 keratin 19, type I
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOA monoamine oxidase A
MT1E metallothionein 1E
MTUS1 microtubule associated tumor suppressor 1
NMU neuromedin U
NSF N-ethylmaleimide-sensitive factor
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SLC22A18 solute carrier family 22, member 18
TARP TCR gamma alternate reading frame protein
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ARL4A ADP-ribosylation factor-like 4A
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BPHL biphenyl hydrolase-like (serine hydrolase)
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FBN2 fibrillin 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GPC4 glypican 4
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IL7R interleukin 7 receptor
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
LBH limb bud and heart development
LPL lipoprotein lipase
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGRN neugrin, neurite outgrowth associated
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP62 nucleoporin 62kDa
OLFML3 olfactomedin-like 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCA protein kinase C, alpha
PROM1 prominin 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTN pleiotrophin
RBM15B RNA binding motif protein 15B
RGCC regulator of cell cycle
RPL10 ribosomal protein L10
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SCGB2A2 secretoglobin, family 2A, member 2
SOX2 SRY (sex determining region Y)-box 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNM synemin, intermediate filament protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS3 tensin 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
USP3 ubiquitin specific peptidase 3
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZNF586 zinc finger protein 586