BRD-A13122391_16-HYDROXYTRIPTOLIDE_A549_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_A549_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABLIM1 actin binding LIM protein 1
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AGA aspartylglucosaminidase
ALOX5 arachidonate 5-lipoxygenase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOD apolipoprotein D
ASPN asporin
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BACE2 beta-site APP-cleaving enzyme 2
BCAM basal cell adhesion molecule (Lutheran blood group)
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFI complement factor I
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTSK cathepsin K
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
ELOVL5 ELOVL fatty acid elongase 5
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD6 frizzled class receptor 6
GLG1 golgi glycoprotein 1
GPM6A glycoprotein M6A
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KRT23 keratin 23, type I
LAGE3 L antigen family, member 3
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MARCO macrophage receptor with collagenous structure
MEIS2 Meis homeobox 2
MMP11 matrix metallopeptidase 11
NCF2 neutrophil cytosolic factor 2
NMU neuromedin U
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDGFRL platelet-derived growth factor receptor-like
PDLIM3 PDZ and LIM domain 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLTP phospholipid transfer protein
PSPH phosphoserine phosphatase
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS10 regulator of G-protein signaling 10
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SNAP25 synaptosomal-associated protein, 25kDa
SNX10 sorting nexin 10
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ATAD2B ATPase family, AAA domain containing 2B
AURKA aurora kinase A
AXIN1 axin 1
BASP1 brain abundant, membrane attached signal protein 1
BCL7B B-cell CLL/lymphoma 7B
BHLHE40 basic helix-loop-helix family, member e40
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CASC3 cancer susceptibility candidate 3
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD1 chromodomain helicase DNA binding protein 1
CLK4 CDC-like kinase 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CREB1 cAMP responsive element binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK10 dedicator of cytokinesis 10
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GOLGA4 golgin A4
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IL6R interleukin 6 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KLHL9 kelch-like family member 9
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MRPS2 mitochondrial ribosomal protein S2
MSL2 male-specific lethal 2 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOTCH2NL notch 2 N-terminal like
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PCGF1 polycomb group ring finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PROM1 prominin 1
RANBP2 RAN binding protein 2
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMNDC1 survival motor neuron domain containing 1
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SPATA2 spermatogenesis associated 2
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
SYNE1 spectrin repeat containing, nuclear envelope 1
TBL1X transducin (beta)-like 1X-linked
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TLE4 transducin-like enhancer of split 4
TNC tenascin C
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TRAM2 translocation associated membrane protein 2
TSC22D2 TSC22 domain family, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
VCAN versican
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR43 WD repeat domain 43
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB1 zinc finger and BTB domain containing 1