BRD-A13021932_BMS509744_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-A13021932_BMS509744_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP3 aquaporin 3 (Gill blood group)
BHLHE41 basic helix-loop-helix family, member e41
BZW2 basic leucine zipper and W2 domains 2
CA1 carbonic anhydrase I
CFB complement factor B
COBL cordon-bleu WH2 repeat protein
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DHCR24 24-dehydrocholesterol reductase
DSP desmoplakin
DYNLT3 dynein, light chain, Tctex-type 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FBP1 fructose-1,6-bisphosphatase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GLUL glutamate-ammonia ligase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
INSIG1 insulin induced gene 1
ITGB4 integrin, beta 4
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF5 Kruppel-like factor 5 (intestinal)
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAMLD1 mastermind-like domain containing 1
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
OPTN optineurin
PECR peroxisomal trans-2-enoyl-CoA reductase
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STS steroid sulfatase (microsomal), isozyme S
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
VNN1 vanin 1
WASF3 WAS protein family, member 3
WDR45 WD repeat domain 45
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
BTG3 BTG family, member 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD24 CD24 molecule
CENPU centromere protein U
COL6A1 collagen, type VI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
E2F2 E2F transcription factor 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGLL1 immunoglobulin lambda-like polypeptide 1
JAM3 junctional adhesion molecule 3
KIAA0101 KIAA0101
MALL mal, T-cell differentiation protein-like
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
OLFML3 olfactomedin-like 3
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PFN2 profilin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RCAN1 regulator of calcineurin 1
RRM2 ribonucleotide reductase M2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRPX sushi-repeat containing protein, X-linked
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WWTR1 WW domain containing transcription regulator 1