BRD-A13021932_BMS509744_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

342 genes differentially expressed following the BRD-A13021932_BMS509744_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CST1 cystatin SN
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBD hemoglobin, delta
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
INHBB inhibin, beta B
JAG1 jagged 1
KDM4B lysine (K)-specific demethylase 4B
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MAST4 microtubule associated serine/threonine kinase family member 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MKRN1 makorin ring finger protein 1
MLPH melanophilin
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NBEA neurobeachin
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
OLFM4 olfactomedin 4
OPTN optineurin
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PPL periplakin
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RAP1GAP RAP1 GTPase activating protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
STOM stomatin
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP9X ubiquitin specific peptidase 9, X-linked
VCL vinculin
VDAC1 voltage-dependent anion channel 1
VIM vimentin
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP4 aquaporin 4
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
C20ORF27 chromosome 20 open reading frame 27
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPM centromere protein M
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CFH complement factor H
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHL1 cell adhesion molecule L1-like
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DOK5 docking protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
GFAP glial fibrillary acidic protein
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
IFI44 interferon-induced protein 44
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO4 LIM domain only 4
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMC3IP PSMC3 interacting protein
PSRC1 proline/serine-rich coiled-coil 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB5C RAB5C, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD1 SMAD family member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN2 transgelin 2
TDO2 tryptophan 2,3-dioxygenase
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM100 transmembrane protein 100
TMPO thymopoietin
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOMM34 translocase of outer mitochondrial membrane 34
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP1 ubiquitin specific peptidase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZIC1 Zic family member 1
ZWINT ZW10 interacting kinetochore protein