BRD-A13021932_BMS509744_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

286 genes differentially expressed following the BRD-A13021932_BMS509744_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
BZW2 basic leucine zipper and W2 domains 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CPM carboxypeptidase M
CTSA cathepsin A
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNM1 dynamin 1
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EDN3 endothelin 3
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FAM50A family with sequence similarity 50, member A
FAM63A family with sequence similarity 63, member A
FBLN1 fibulin 1
FBLN2 fibulin 2
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GCC2 GRIP and coiled-coil domain containing 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRAMD3 GRAM domain containing 3
GRN granulin
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT18 keratin 18, type I
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00342 long intergenic non-protein coding RNA 342
LRP10 low density lipoprotein receptor-related protein 10
LY75 lymphocyte antigen 75
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MUC13 mucin 13, cell surface associated
MVP major vault protein
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PINK1 PTEN induced putative kinase 1
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
RHOF ras homolog family member F (in filopodia)
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STOM stomatin
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMC5 transmembrane channel-like 5
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIM8 tripartite motif containing 8
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
VIM vimentin
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FKBP5 FK506 binding protein 5
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFRD2 interferon-related developmental regulator 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MSH6 mutS homolog 6
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NKX3-1 NK3 homeobox 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PAX5 paired box 5
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PFN2 profilin 2
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRC1 protein regulator of cytokinesis 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTTG1 pituitary tumor-transforming 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS4 regulator of G-protein signaling 4
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TDO2 tryptophan 2,3-dioxygenase
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPRKB TP53RK binding protein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VRK1 vaccinia related kinase 1
XIST X inactive specific transcript (non-protein coding)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein