BRD-A13021932_BMS509744_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-A13021932_BMS509744_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL5 chemokine (C-C motif) ligand 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FZD7 frizzled class receptor 7
GLUD1 glutamate dehydrogenase 1
GPC3 glypican 3
GPX2 glutathione peroxidase 2
GSN gelsolin
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
KDM5D lysine (K)-specific demethylase 5D
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS2 lectin, galactoside-binding, soluble, 2
LRP10 low density lipoprotein receptor-related protein 10
LTF lactotransferrin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MTUS1 microtubule associated tumor suppressor 1
NEFL neurofilament, light polypeptide
NSDHL NAD(P) dependent steroid dehydrogenase-like
OXTR oxytocin receptor
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PTX3 pentraxin 3, long
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TGFBR3 transforming growth factor, beta receptor III
TMED3 transmembrane emp24 protein transport domain containing 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TWF2 twinfilin actin binding protein 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADA adenosine deaminase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARMCX2 armadillo repeat containing, X-linked 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKS1B CDC28 protein kinase regulatory subunit 1B
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CXCL12 chemokine (C-X-C motif) ligand 12
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNTT DNA nucleotidylexotransferase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB2 high mobility group box 2
IGFBP7 insulin-like growth factor binding protein 7
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PXDN peroxidasin
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SEPW1 selenoprotein W, 1
SOX4 SRY (sex determining region Y)-box 4
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VCAN versican
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein