BRD-A13021932_BMS509744_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

228 genes differentially expressed following the BRD-A13021932_BMS509744_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADCY9 adenylate cyclase 9
AGR2 anterior gradient 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP9A ATPase, class II, type 9A
C9ORF3 chromosome 9 open reading frame 3
CAPN1 calpain 1, (mu/I) large subunit
CCDC92 coiled-coil domain containing 92
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPNE3 copine III
CST1 cystatin SN
CST3 cystatin C
CTSA cathepsin A
CTSC cathepsin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DMTF1 cyclin D binding myb-like transcription factor 1
DYNLT3 dynein, light chain, Tctex-type 3
F13A1 coagulation factor XIII, A1 polypeptide
FGF13 fibroblast growth factor 13
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
GLRX glutaredoxin (thioltransferase)
GMPR2 guanosine monophosphate reductase 2
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HDAC6 histone deacetylase 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ISCU iron-sulfur cluster assembly enzyme
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LRP10 low density lipoprotein receptor-related protein 10
LTA4H leukotriene A4 hydrolase
MAB21L2 mab-21-like 2 (C. elegans)
MACF1 microtubule-actin crosslinking factor 1
MAOA monoamine oxidase A
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NRP1 neuropilin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OXA1L oxidase (cytochrome c) assembly 1-like
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAIP1 poly(A) binding protein interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGD phosphogluconate dehydrogenase
PLA2G16 phospholipase A2, group XVI
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SYBU syntabulin (syntaxin-interacting)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMX4 thioredoxin-related transmembrane protein 4
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
USP22 ubiquitin specific peptidase 22
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BCHE butyrylcholinesterase
BPHL biphenyl hydrolase-like (serine hydrolase)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHEK1 checkpoint kinase 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A2 collagen, type VI, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5 eukaryotic translation initiation factor 5
EMX2 empty spiracles homeobox 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOPX HOP homeobox
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MFSD10 major facilitator superfamily domain containing 10
MT1M metallothionein 1M
MTERF3 mitochondrial transcription termination factor 3
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NKX3-1 NK3 homeobox 1
ORC1 origin recognition complex, subunit 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PSPH phosphoserine phosphatase
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SEPT11 septin 11
SHCBP1 SHC SH2-domain binding protein 1
SLBP stem-loop binding protein
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC43A3 solute carrier family 43, member 3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX30 testis expressed 30
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein