BRD-A13021932_BMS509744_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-A13021932_BMS509744_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AGA aspartylglucosaminidase
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BZW2 basic leucine zipper and W2 domains 2
C16ORF45 chromosome 16 open reading frame 45
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHMP1B charged multivesicular body protein 1B
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CTSE cathepsin E
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUOX2 dual oxidase 2
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FADS1 fatty acid desaturase 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAGE3 G antigen 3
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KYNU kynureninase
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPAS2 neuronal PAS domain protein 2
NPDC1 neural proliferation, differentiation and control, 1
NPEPL1 aminopeptidase-like 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1 runt-related transcription factor 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SLC16A6 solute carrier family 16, member 6
SLC22A18 solute carrier family 22, member 18
SORD sorbitol dehydrogenase
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SSX1 synovial sarcoma, X breakpoint 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TCEAL4 transcription elongation factor A (SII)-like 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TST thiosulfate sulfurtransferase (rhodanese)
VCAN versican
VEGFC vascular endothelial growth factor C
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANXA3 annexin A3
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT1 dynein, light chain, Tctex-type 1
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
EPHA3 EPH receptor A3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FAM171A1 family with sequence similarity 171, member A1
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMPR guanosine monophosphate reductase
GTSE1 G-2 and S-phase expressed 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LHX2 LIM homeobox 2
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PAX5 paired box 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QKI QKI, KH domain containing, RNA binding
RACGAP1 Rac GTPase activating protein 1
RAD21 RAD21 homolog (S. pombe)
RFC4 replication factor C (activator 1) 4, 37kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
SEPHS1 selenophosphate synthetase 1
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPC25 SPC25, NDC80 kinetochore complex component
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TCERG1 transcription elongation regulator 1
TCTN1 tectonic family member 1
TEX30 testis expressed 30
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TWF1 twinfilin actin binding protein 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein