BRD-A12230535_Nutlin-3_HA1E_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

118 genes differentially expressed following the BRD-A12230535_Nutlin-3_HA1E_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CARS cysteinyl-tRNA synthetase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC5A C-type lectin domain family 5, member A
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IARS isoleucyl-tRNA synthetase
IL1A interleukin 1, alpha
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAX8 paired box 8
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SARS seryl-tRNA synthetase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TFPI2 tissue factor pathway inhibitor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADI1 acireductone dioxygenase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CBR3 carbonyl reductase 3
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CNN1 calponin 1, basic, smooth muscle
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCK deoxycytidine kinase
ECI2 enoyl-CoA delta isomerase 2
EGF epidermal growth factor
ENDOD1 endonuclease domain containing 1
ESD esterase D
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
LBH limb bud and heart development
MAGED1 melanoma antigen family D1
MAP2K6 mitogen-activated protein kinase kinase 6
MBNL1 muscleblind-like splicing regulator 1
OSBPL8 oxysterol binding protein-like 8
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SEPT11 septin 11
SKP1 S-phase kinase-associated protein 1
SPRR1A small proline-rich protein 1A
TBC1D4 TBC1 domain family, member 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TMX4 thioredoxin-related transmembrane protein 4
TUBB2A tubulin, beta 2A class IIa
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)