BRD-A12230535_Nutlin-3_A549_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-A12230535_Nutlin-3_A549_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2B integral membrane protein 2B
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LMNA lamin A/C
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
NAV2 neuron navigator 2
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF24 ring finger protein 24
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
STC2 stanniocalcin 2
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53I3 tumor protein p53 inducible protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPA centromere protein A
COG2 component of oligomeric golgi complex 2
CP ceruloplasmin (ferroxidase)
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EXOSC4 exosome component 4
FAM111A family with sequence similarity 111, member A
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KLHL23 kelch-like family member 23
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MPHOSPH9 M-phase phosphoprotein 9
NAP1L1 nucleosome assembly protein 1-like 1
NDRG3 NDRG family member 3
NMU neuromedin U
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
NTS neurotensin
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
PON2 paraoxonase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
SORD sorbitol dehydrogenase
SUMO2 small ubiquitin-like modifier 2
TMEM14A transmembrane protein 14A
TMPO thymopoietin
WT1 Wilms tumor 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta