BRD-A12230535_Nutlin-3_A375_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

51 genes differentially expressed following the BRD-A12230535_Nutlin-3_A375_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATF3 activating transcription factor 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGR1 early growth response 1
FAM69A family with sequence similarity 69, member A
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LIF leukemia inhibitory factor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PON3 paraoxonase 3
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
SDC4 syndecan 4
SFRP4 secreted frizzled-related protein 4
SNAI2 snail family zinc finger 2
SPRED2 sprouty-related, EVH1 domain containing 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
CCND1 cyclin D1
CDK1 cyclin-dependent kinase 1
CPVL carboxypeptidase, vitellogenic-like
DKK1 dickkopf WNT signaling pathway inhibitor 1
GAS2L1 growth arrest-specific 2 like 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HMGN3 high mobility group nucleosomal binding domain 3
HOXC6 homeobox C6
IQGAP2 IQ motif containing GTPase activating protein 2
KANK2 KN motif and ankyrin repeat domains 2
LMNB1 lamin B1
PRDX2 peroxiredoxin 2
PXMP2 peroxisomal membrane protein 2, 22kDa
SORD sorbitol dehydrogenase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMSB15A thymosin beta 15a