BRD-A12230535_Nutlin-3_A375_24.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

426 genes differentially expressed following the BRD-A12230535_Nutlin-3_A375_24.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C1ORF116 chromosome 1 open reading frame 116
C9ORF3 chromosome 9 open reading frame 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND1B DENN/MADD domain containing 1B
DES desmin
DGKA diacylglycerol kinase, alpha 80kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
EPS8L2 EPS8-like 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETHE1 ethylmalonic encephalopathy 1
FAM198B family with sequence similarity 198, member B
FAM69A family with sequence similarity 69, member A
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
GAB2 GRB2-associated binding protein 2
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPX2 glutathione peroxidase 2
GSDMB gasdermin B
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IL1B interleukin 1, beta
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KRT14 keratin 14, type I
LDB3 LIM domain binding 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIMK2 LIM domain kinase 2
LPAR6 lysophosphatidic acid receptor 6
LRP10 low density lipoprotein receptor-related protein 10
LY96 lymphocyte antigen 96
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM4 olfactomedin 4
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PRUNE2 prune homolog 2 (Drosophila)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGCC regulator of cell cycle
RIPK4 receptor-interacting serine-threonine kinase 4
SARS seryl-tRNA synthetase
SCD5 stearoyl-CoA desaturase 5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNC1 troponin C type 1 (slow)
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WFDC1 WAP four-disulfide core domain 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA6 annexin A6
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP19 Rho GTPase activating protein 19
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BMPR1A bone morphogenetic protein receptor, type IA
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
C20ORF27 chromosome 20 open reading frame 27
CALD1 caldesmon 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBR3 carbonyl reductase 3
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPI centromere protein I
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL4A2 collagen, type IV, alpha 2
COL9A3 collagen, type IX, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1 dynamin 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EDNRB endothelin receptor type B
EIF4A3 eukaryotic translation initiation factor 4A3
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM111A family with sequence similarity 111, member A
FAM35A family with sequence similarity 35, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLTF helicase-like transcription factor
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPB11 heat shock protein family B (small), member 11
ICMT isoprenylcysteine carboxyl methyltransferase
ITGB5 integrin, beta 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LEPR leptin receptor
LMNB1 lamin B1
LMNB2 lamin B2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NOTCH2 notch 2
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP210 nucleoporin 210kDa
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB11A RAB11A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA1 replication protein A1, 70kDa
RPA3 replication protein A3, 14kDa
RPP25 ribonuclease P/MRP 25kDa subunit
RPP30 ribonuclease P/MRP 30kDa subunit
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SAP30 Sin3A-associated protein, 30kDa
SEPHS1 selenophosphate synthetase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC43A3 solute carrier family 43, member 3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPF small nuclear ribonucleoprotein polypeptide F
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPAG5 sperm associated antigen 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF2 serine/arginine-rich splicing factor 2
STIL SCL/TAL1 interrupting locus
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBL1X transducin (beta)-like 1X-linked
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM14A transmembrane protein 14A
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPO1 exportin 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein