BRD-A11702965_230752_PHH_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-A11702965_230752_PHH_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AQP1 aquaporin 1 (Colton blood group)
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CXCL14 chemokine (C-X-C motif) ligand 14
DDR1 discoidin domain receptor tyrosine kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENDOD1 endonuclease domain containing 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
HDAC9 histone deacetylase 9
HIP1 huntingtin interacting protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD12 potassium channel tetramerization domain containing 12
LDOC1 leucine zipper, down-regulated in cancer 1
LPL lipoprotein lipase
LPPR4 lipid phosphate phosphatase-related protein type 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MEIS1 Meis homeobox 1
MICB MHC class I polypeptide-related sequence B
MRC2 mannose receptor, C type 2
MX2 MX dynamin-like GTPase 2
PLIN1 perilipin 1
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS4 regulator of G-protein signaling 4
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SERTAD2 SERTA domain containing 2
SH3YL1 SH3 and SYLF domain containing 1
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
TCTA T-cell leukemia translocation altered
THBS4 thrombospondin 4
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRD T cell receptor delta locus
TXNIP thioredoxin interacting protein
WT1 Wilms tumor 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOC1 apolipoprotein C-I
APOH apolipoprotein H (beta-2-glycoprotein I)
ARG1 arginase 1
ASPH aspartate beta-hydroxylase
ATG3 autophagy related 3
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIRC3 baculoviral IAP repeat containing 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CD27 CD27 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CHGB chromogranin B
CLTA clathrin, light chain A
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CTSC cathepsin C
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FGB fibrinogen beta chain
FGF13 fibroblast growth factor 13
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLRX glutaredoxin (thioltransferase)
GSTA1 glutathione S-transferase alpha 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0368 KIAA0368
KYNU kynureninase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MRPL42 mitochondrial ribosomal protein L42
MRPS12 mitochondrial ribosomal protein S12
MRPS16 mitochondrial ribosomal protein S16
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MTF2 metal response element binding transcription factor 2
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NOL4 nucleolar protein 4
NPY1R neuropeptide Y receptor Y1
ORM1 orosomucoid 1
PCM1 pericentriolar material 1
PELO pelota homolog (Drosophila)
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSAP prosaposin
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
RAD23B RAD23 homolog B (S. cerevisiae)
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC62 SEC62 homolog (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SEPT9 septin 9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SET SET nuclear proto-oncogene
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USP22 ubiquitin specific peptidase 22
WSB2 WD repeat and SOCS box containing 2
ZBTB20 zinc finger and BTB domain containing 20