BRD-A11702965_230752_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-A11702965_230752_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AIDA axin interactor, dorsalization associated
ALDOB aldolase B, fructose-bisphosphate
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BSG basigin (Ok blood group)
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD302 CD302 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD9 CD9 molecule
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DCN decorin
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSE dermatan sulfate epimerase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ENSA endosulfine alpha
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERAP1 endoplasmic reticulum aminopeptidase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GAS6 growth arrest-specific 6
GNLY granulysin
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
ITGAV integrin, alpha V
ITGB7 integrin, beta 7
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LITAF lipopolysaccharide-induced TNF factor
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
NELL2 NEL-like 2 (chicken)
NTS neurotensin
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLD3 phospholipase D family, member 3
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC1 stanniocalcin 1
SULF1 sulfatase 1
TARP TCR gamma alternate reading frame protein
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TYROBP TYRO protein tyrosine kinase binding protein
UGP2 UDP-glucose pyrophosphorylase 2
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZDHHC4 zinc finger, DHHC-type containing 4

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADORA2B adenosine A2b receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARF6 ADP-ribosylation factor 6
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
C14ORF166 chromosome 14 open reading frame 166
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHERP calcium homeostasis endoplasmic reticulum protein
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CUL2 cullin 2
CXCL6 chemokine (C-X-C motif) ligand 6
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
ECD ecdysoneless homolog (Drosophila)
EFNB2 ephrin-B2
EHD1 EH-domain containing 1
EIF4A3 eukaryotic translation initiation factor 4A3
ELAVL1 ELAV like RNA binding protein 1
FABP7 fatty acid binding protein 7, brain
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLOD4 glyoxalase domain containing 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KLC1 kinesin light chain 1
KLK6 kallikrein-related peptidase 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAX MYC associated factor X
MCL1 myeloid cell leukemia 1
MED6 mediator complex subunit 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTERF3 mitochondrial transcription termination factor 3
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKCD protein kinase C, delta
PRKCDBP protein kinase C, delta binding protein
PROM1 prominin 1
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RIT1 Ras-like without CAAX 1
RNPS1 RNA binding protein S1, serine-rich domain
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCEL sciellin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SPRR3 small proline-rich protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM97 transmembrane protein 97
TNC tenascin C
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRIM16 tripartite motif containing 16
TSC22D1 TSC22 domain family, member 1
TSPAN14 tetraspanin 14
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
USP22 ubiquitin specific peptidase 22
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2