BRD-A11702965_230752_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

271 genes differentially expressed following the BRD-A11702965_230752_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AHCYL1 adenosylhomocysteinase-like 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPD carboxypeptidase D
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM198B family with sequence similarity 198, member B
FBN1 fibrillin 1
FBXL7 F-box and leucine-rich repeat protein 7
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN4 high mobility group nucleosomal binding domain 4
HOPX HOP homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA1462 KIAA1462
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MFN2 mitofusin 2
MSLN mesothelin
MSN moesin
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NID1 nidogen 1
NLRP2 NLR family, pyrin domain containing 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLS3 plastin 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCARB2 scavenger receptor class B, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
TSPAN12 tetraspanin 12
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
VGLL1 vestigial-like family member 1
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCAS3 breast carcinoma amplified sequence 3
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CNOT7 CCR4-NOT transcription complex, subunit 7
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAZAP2 DAZ associated protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ESR1 estrogen receptor 1
ETNK1 ethanolamine kinase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM35A family with sequence similarity 35, member A
FHL2 four and a half LIM domains 2
FOXJ3 forkhead box J3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GLOD4 glyoxalase domain containing 4
GTPBP8 GTP-binding protein 8 (putative)
HN1 hematological and neurological expressed 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KYNU kynureninase
LTF lactotransferrin
MCAM melanoma cell adhesion molecule
MIA melanoma inhibitory activity
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MYBPC1 myosin binding protein C, slow type
NIT2 nitrilase family, member 2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFDN4 prefoldin subunit 4
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RET ret proto-oncogene
RFK riboflavin kinase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SCAND1 SCAN domain containing 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP1 t-complex 1
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TNPO1 transportin 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon