BRD-A11702965_230752_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-A11702965_230752_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
C9ORF16 chromosome 9 open reading frame 16
CCND2 cyclin D2
CD47 CD47 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CTBS chitobiase, di-N-acetyl-
CTSV cathepsin V
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
DCT dopachrome tautomerase
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EID1 EP300 interacting inhibitor of differentiation 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPM6A glycoprotein M6A
GSTA4 glutathione S-transferase alpha 4
HLTF helicase-like transcription factor
HOMER2 homer scaffolding protein 2
IFITM1 interferon induced transmembrane protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KRT4 keratin 4, type II
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRC2 mannose receptor, C type 2
MXRA5 matrix-remodelling associated 5
NREP neuronal regeneration related protein
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PFKM phosphofructokinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PRAME preferentially expressed antigen in melanoma
PRTN3 proteinase 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF4 transcription factor 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG5 BCL2-associated athanogene 5
BFAR bifunctional apoptosis regulator
BMP2 bone morphogenetic protein 2
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C15ORF39 chromosome 15 open reading frame 39
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COASY CoA synthase
CSRP1 cysteine and glycine-rich protein 1
DBF4 DBF4 zinc finger
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGFR epidermal growth factor receptor
ELOVL2 ELOVL fatty acid elongase 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GOSR1 golgi SNAP receptor complex member 1
GSPT2 G1 to S phase transition 2
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIF18A kinesin family member 18A
KRT18 keratin 18, type I
MAD2L1BP MAD2L1 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MTF2 metal response element binding transcription factor 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PALB2 partner and localizer of BRCA2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRPF4 pre-mRNA processing factor 4
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RHOBTB3 Rho-related BTB domain containing 3
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SDC4 syndecan 4
SEC24B SEC24 family member B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SFN stratifin
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBX3 T-box 3
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSKU tsukushi, small leucine rich proteoglycan
TTF1 transcription termination factor, RNA polymerase I
TXLNA taxilin alpha
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2