BRD-A11702965_230752_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-A11702965_230752_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
CAPN3 calpain 3, (p94)
CD14 CD14 molecule
CD177 CD177 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CPM carboxypeptidase M
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
F13A1 coagulation factor XIII, A1 polypeptide
FBN1 fibrillin 1
FBN2 fibrillin 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LTF lactotransferrin
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
MXRA5 matrix-remodelling associated 5
NPC1 Niemann-Pick disease, type C1
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBPL1A oxysterol binding protein-like 1A
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG3 paternally expressed 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
REEP5 receptor accessory protein 5
RHOQ ras homolog family member Q
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TNNC1 troponin C type 1 (slow)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BCL10 B-cell CLL/lymphoma 10
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C12ORF43 chromosome 12 open reading frame 43
C14ORF169 chromosome 14 open reading frame 169
C1ORF106 chromosome 1 open reading frame 106
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC6 cell division cycle 6
CDK7 cyclin-dependent kinase 7
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP350 centrosomal protein 350kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP1 cysteine and glycine-rich protein 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EXO1 exonuclease 1
FADD Fas (TNFRSF6)-associated via death domain
FAM63A family with sequence similarity 63, member A
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GEMIN4 gem (nuclear organelle) associated protein 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HAUS3 HAUS augmin-like complex, subunit 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
LCMT2 leucine carboxyl methyltransferase 2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1BP MAD2L1 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MIEF1 mitochondrial elongation factor 1
MIS12 MIS12 kinetochore complex component
MRPL46 mitochondrial ribosomal protein L46
MRPS31 mitochondrial ribosomal protein S31
MTF2 metal response element binding transcription factor 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPAT nuclear protein, ataxia-telangiectasia locus
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PHF20 PHD finger protein 20
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRPF4 pre-mRNA processing factor 4
RAB14 RAB14, member RAS oncogene family
RANBP6 RAN binding protein 6
RBM34 RNA binding motif protein 34
RBM48 RNA binding motif protein 48
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RNF4 ring finger protein 4
RNMTL1 RNA methyltransferase like 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC24B SEC24 family member B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNRK SNF related kinase
SPATA5L1 spermatogenesis associated 5-like 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TEX30 testis expressed 30
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TTF1 transcription termination factor, RNA polymerase I
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UMPS uridine monophosphate synthetase
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF200 zinc finger protein 200
ZNF267 zinc finger protein 267
ZNF292 zinc finger protein 292
ZNF652 zinc finger protein 652