BRD-A11702965_230752_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-A11702965_230752_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFH complement factor H
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLEC10A C-type lectin domain family 10, member A
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
FABP1 fatty acid binding protein 1, liver
FAM198B family with sequence similarity 198, member B
FBLN1 fibulin 1
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGL immunoglobulin lambda locus
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA1462 KIAA1462
KPNB1 karyopherin (importin) beta 1
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
NCF2 neutrophil cytosolic factor 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAM peptidylglycine alpha-amidating monooxygenase
PAWR PRKC, apoptosis, WT1, regulator
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STS steroid sulfatase (microsomal), isozyme S
TCF21 transcription factor 21
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNS1 tensin 1
TUBA1A tubulin, alpha 1a
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BCL3 B-cell CLL/lymphoma 3
BLCAP bladder cancer associated protein
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPB centromere protein B, 80kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETV5 ets variant 5
FAM102A family with sequence similarity 102, member A
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT7 keratin 7, type II
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MEPCE methylphosphate capping enzyme
MID1 midline 1
MT2A metallothionein 2A
MTF2 metal response element binding transcription factor 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PANK2 pantothenate kinase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMP22 peripheral myelin protein 22
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
PYGB phosphorylase, glycogen; brain
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RHOF ras homolog family member F (in filopodia)
RPL36 ribosomal protein L36
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC24A SEC24 family member A
SESN1 sestrin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMOX spermine oxidase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNX5 sorting nexin 5
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF11 serine/arginine-rich splicing factor 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBR3 transforming growth factor, beta receptor III
TICAM1 toll-like receptor adaptor molecule 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TMEM11 transmembrane protein 11
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIP6 thyroid hormone receptor interactor 6
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91