BRD-A11678676_Wortmannin_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-A11678676_Wortmannin_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
BGN biglycan
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYTIP cytohesin 1 interacting protein
DSP desmoplakin
EZR ezrin
FHL1 four and a half LIM domains 1
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF6 Kruppel-like factor 6
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
NPC1 Niemann-Pick disease, type C1
PDLIM5 PDZ and LIM domain 5
PPARD peroxisome proliferator-activated receptor delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SRGN serglycin
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
VCAM1 vascular cell adhesion molecule 1
VCAN versican

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADORA2B adenosine A2b receptor
AK2 adenylate kinase 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AURKA aurora kinase A
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFAP20 cilia and flagella associated protein 20
CHPT1 choline phosphotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
FAM216A family with sequence similarity 216, member A
GEMIN6 gem (nuclear organelle) associated protein 6
GMDS GDP-mannose 4,6-dehydratase
HSPA1A heat shock 70kDa protein 1A
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
MCAM melanoma cell adhesion molecule
MLEC malectin
MRPL3 mitochondrial ribosomal protein L3
MSLN mesothelin
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PHB prohibitin
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTTG1 pituitary tumor-transforming 1
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF7 serine/arginine-rich splicing factor 7
TFRC transferrin receptor
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TOX thymocyte selection-associated high mobility group box
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3