BRD-A11678676_Wortmannin_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A11678676_Wortmannin_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOD apolipoprotein D
AREG amphiregulin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A5 collagen, type IV, alpha 5
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
FOXO4 forkhead box O4
GSTA1 glutathione S-transferase alpha 1
LPAR6 lysophosphatidic acid receptor 6
MTMR11 myotubularin related protein 11
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
SEPP1 selenoprotein P, plasma, 1
STON1 stonin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS3 thrombospondin 3
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AURKA aurora kinase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB2 cyclin B2
CD320 CD320 molecule
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5 eukaryotic translation initiation factor 5
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
FASN fatty acid synthase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MRPS30 mitochondrial ribosomal protein S30
NCAPG non-SMC condensin I complex, subunit G
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRC1 protein regulator of cytokinesis 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RPA3 replication protein A3, 14kDa
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RRM2 ribonucleotide reductase M2
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
TACC3 transforming, acidic coiled-coil containing protein 3
TPX2 TPX2, microtubule-associated
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S