BRD-A11678676_Wortmannin_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-A11678676_Wortmannin_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BEX4 brain expressed, X-linked 4
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD9 CD9 molecule
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTSA cathepsin A
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFHD1 EF-hand domain family, member D1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRN granulin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
INA internexin neuronal intermediate filament protein, alpha
JUP junction plakoglobin
KIAA0040 KIAA0040
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MLPH melanophilin
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYO5C myosin VC
NVL nuclear VCP-like
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PON3 paraoxonase 3
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBM47 RNA binding motif protein 47
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SLC38A1 solute carrier family 38, member 1
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
SYT1 synaptotagmin I
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TYMP thymidine phosphorylase
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPRIN2 caprin family member 2
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FERMT2 fermitin family member 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF2C kinesin family member 2C
LMO4 LIM domain only 4
LOX lysyl oxidase
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
RRM1 ribonucleotide reductase M1
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
TACC3 transforming, acidic coiled-coil containing protein 3
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
WNT5A wingless-type MMTV integration site family, member 5A
YME1L1 YME1-like 1 ATPase
ZWILCH zwilch kinetochore protein