BRD-A11678676_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-A11678676_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGTR1 angiotensin II receptor, type 1
BASP1 brain abundant, membrane attached signal protein 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD59 CD59 molecule, complement regulatory protein
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CUTA cutA divalent cation tolerance homolog (E. coli)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
FAM134A family with sequence similarity 134, member A
FAM63A family with sequence similarity 63, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRN granulin
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IRF9 interferon regulatory factor 9
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LXN latexin
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYLK myosin light chain kinase
MYO6 myosin VI
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PLXND1 plexin D1
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TRAF5 TNF receptor-associated factor 5
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TXNIP thioredoxin interacting protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARPC5L actin related protein 2/3 complex, subunit 5-like
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DCN decorin
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5 eukaryotic translation initiation factor 5
EXOSC9 exosome component 9
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDC1 NDC1 transmembrane nucleoporin
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
RBP1 retinol binding protein 1, cellular
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SHCBP1 SHC SH2-domain binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SRPRB signal recognition particle receptor, B subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C