BRD-A11605036_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-A11605036_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD28 ankyrin repeat domain 28
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BTK Bruton agammaglobulinemia tyrosine kinase
C1S complement component 1, s subcomponent
CADM1 cell adhesion molecule 1
CBR1 carbonyl reductase 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CPM carboxypeptidase M
CREG1 cellular repressor of E1A-stimulated genes 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR1 fibroblast growth factor receptor 1
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCH1 GTP cyclohydrolase 1
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GRAMD1B GRAM domain containing 1B
GRB14 growth factor receptor-bound protein 14
GULP1 GULP, engulfment adaptor PTB domain containing 1
HP haptoglobin
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IL4R interleukin 4 receptor
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KRT15 keratin 15, type I
KRT16 keratin 16, type I
LINC00341 long intergenic non-protein coding RNA 341
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAST4 microtubule associated serine/threonine kinase family member 4
MBNL2 muscleblind-like splicing regulator 2
MRPL19 mitochondrial ribosomal protein L19
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTA1 metastasis associated 1
MUC1 mucin 1, cell surface associated
MXD4 MAX dimerization protein 4
MYO5C myosin VC
NCK1 NCK adaptor protein 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
PLEC plectin
PLTP phospholipid transfer protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAP1GAP RAP1 GTPase activating protein
RBM47 RNA binding motif protein 47
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
S100A11 S100 calcium binding protein A11
S100A13 S100 calcium binding protein A13
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR2B small proline-rich protein 2B
SPTBN1 spectrin, beta, non-erythrocytic 1
SQRDL sulfide quinone reductase-like (yeast)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAMBP STAM binding protein
STAR steroidogenic acute regulatory protein
SYK spleen tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNS3 tensin 3
TRIM29 tripartite motif containing 29
VSNL1 visinin-like 1
WFS1 Wolfram syndrome 1 (wolframin)
WRB tryptophan rich basic protein
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD163 CD163 molecule
CD164 CD164 molecule, sialomucin
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FKBP1A FK506 binding protein 1A, 12kDa
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
H1FX H1 histone family, member X
HOPX HOP homeobox
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFRD1 interferon-related developmental regulator 1
INSM1 insulinoma-associated 1
KRT20 keratin 20, type I
LDLR low density lipoprotein receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MMP10 matrix metallopeptidase 10
NDN necdin, melanoma antigen (MAGE) family member
NEB nebulin
NELL2 NEL-like 2 (chicken)
NXN nucleoredoxin
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PDLIM3 PDZ and LIM domain 3
PEA15 phosphoprotein enriched in astrocytes 15
PID1 phosphotyrosine interaction domain containing 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKP2 plakophilin 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
SEC63 SEC63 homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOWAHC sosondowah ankyrin repeat domain family member C
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TRIL TLR4 interactor with leucine-rich repeats
TUBB2A tubulin, beta 2A class IIa
TULP3 tubby like protein 3
TXNDC9 thioredoxin domain containing 9
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF395 zinc finger protein 395