BRD-A11605036_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-A11605036_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD3 acyl-CoA binding domain containing 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLNK B-cell linker
BTG2 BTG family, member 2
BTK Bruton agammaglobulinemia tyrosine kinase
C21ORF91 chromosome 21 open reading frame 91
C7 complement component 7
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CBR1 carbonyl reductase 1
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD19 CD19 molecule
CD24 CD24 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDA cytidine deaminase
CDC25A cell division cycle 25A
CDK6 cyclin-dependent kinase 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLASRP CLK4-associating serine/arginine rich protein
CLMN calmin (calponin-like, transmembrane)
CLSTN1 calsyntenin 1
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DICER1 dicer 1, ribonuclease type III
DPY19L2P2 DPY19L2 pseudogene 2
EDN1 endothelin 1
ELMO1 engulfment and cell motility 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETV1 ets variant 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRB14 growth factor receptor-bound protein 14
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
KAT6B K(lysine) acetyltransferase 6B
KDM5A lysine (K)-specific demethylase 5A
KDM6A lysine (K)-specific demethylase 6A
KIAA1598
KLHL24 kelch-like family member 24
KLHL9 kelch-like family member 9
KLK5 kallikrein-related peptidase 5
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
KYNU kynureninase
L1CAM L1 cell adhesion molecule
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LTF lactotransferrin
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MMP9 matrix metallopeptidase 9
MRFAP1L1 Morf4 family associated protein 1-like 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC1 mucin 1, cell surface associated
MYO5C myosin VC
NFE2L2 nuclear factor, erythroid 2-like 2
NNT nicotinamide nucleotide transhydrogenase
NOV nephroblastoma overexpressed
OLFM1 olfactomedin 1
PARP1 poly (ADP-ribose) polymerase 1
PASK PAS domain containing serine/threonine kinase
PAX5 paired box 5
PDLIM5 PDZ and LIM domain 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRAME preferentially expressed antigen in melanoma
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCH protein kinase C, eta
PRKX protein kinase, X-linked
PSD3 pleckstrin and Sec7 domain containing 3
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAP1GAP RAP1 GTPase activating protein
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP1B ribosomal RNA processing 1B
S100P S100 calcium binding protein P
SF1 splicing factor 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLPI secretory leukocyte peptidase inhibitor
SORBS2 sorbin and SH3 domain containing 2
SOSTDC1 sclerostin domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAR steroidogenic acute regulatory protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TKTL1 transketolase-like 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AMPH amphiphysin
ANXA1 annexin A1
ATF3 activating transcription factor 3
C1QA complement component 1, q subcomponent, A chain
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD151 CD151 molecule (Raph blood group)
CD163 CD163 molecule
CD164 CD164 molecule, sialomucin
CD36 CD36 molecule (thrombospondin receptor)
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
CSRP2 cysteine and glycine-rich protein 2
CTSH cathepsin H
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DCAF6 DDB1 and CUL4 associated factor 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPYSL3 dihydropyrimidinase-like 3
ECI2 enoyl-CoA delta isomerase 2
ECM1 extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5 eukaryotic translation initiation factor 5
FAM114A1 family with sequence similarity 114, member A1
FAM129A family with sequence similarity 129, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FSTL1 follistatin-like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
GSTT1 glutathione S-transferase theta 1
H1F0 H1 histone family, member 0
H2AFY H2A histone family, member Y
HBB hemoglobin, beta
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LMNA lamin A/C
LOXL2 lysyl oxidase-like 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MTDH metadherin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPTX2 neuronal pentraxin II
OLFML3 olfactomedin-like 3
OXTR oxytocin receptor
PAM peptidylglycine alpha-amidating monooxygenase
PEA15 phosphoprotein enriched in astrocytes 15
PGK1 phosphoglycerate kinase 1
PGLS 6-phosphogluconolactonase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PON2 paraoxonase 2
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
REXO2 RNA exonuclease 2
RGS1 regulator of G-protein signaling 1
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
SEC61G Sec61 gamma subunit
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
SSPN sarcospan
STK39 serine threonine kinase 39
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNM synemin, intermediate filament protein
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TRIOBP TRIO and F-actin binding protein
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
TYROBP TYRO protein tyrosine kinase binding protein
UROD uroporphyrinogen decarboxylase
USP22 ubiquitin specific peptidase 22
VKORC1 vitamin K epoxide reductase complex, subunit 1
ZNF91 zinc finger protein 91