BRD-A11263757_Azacytidine-5_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-A11263757_Azacytidine-5_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIK BCL2-interacting killer (apoptosis-inducing)
C8ORF4 chromosome 8 open reading frame 4
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
F3 coagulation factor III (thromboplastin, tissue factor)
FASN fatty acid synthase
FRMD4B FERM domain containing 4B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1B interleukin 1, beta
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA1324 KIAA1324
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MED1 mediator complex subunit 1
MOAP1 modulator of apoptosis 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMS spermine synthase
STXBP6 syntaxin binding protein 6 (amisyn)
SYNJ2 synaptojanin 2
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ANXA6 annexin A6
AUTS2 autism susceptibility candidate 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KAZN kazrin, periplakin interacting protein
LITAF lipopolysaccharide-induced TNF factor
MMP13 matrix metallopeptidase 13
MSRB1 methionine sulfoxide reductase B1
NID1 nidogen 1
NREP neuronal regeneration related protein
PCP4 Purkinje cell protein 4
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PVALB parvalbumin
RPS11 ribosomal protein S11
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TES testin LIM domain protein
TMEM45A transmembrane protein 45A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)