BRD-A11263757_Azacytidine-5_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-A11263757_Azacytidine-5_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BRD4 bromodomain containing 4
BTBD3 BTB (POZ) domain containing 3
CCL20 chemokine (C-C motif) ligand 20
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPH2 DPH2 homolog (S. cerevisiae)
DPP8 dipeptidyl-peptidase 8
DUSP4 dual specificity phosphatase 4
ELF4 E74-like factor 4 (ets domain transcription factor)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGF2 fibroblast growth factor 2 (basic)
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GTPBP4 GTP binding protein 4
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
INTS6 integrator complex subunit 6
JAG1 jagged 1
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
KRT7 keratin 7, type II
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
LMO4 LIM domain only 4
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMP12 matrix metallopeptidase 12
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSBPL3 oxysterol binding protein-like 3
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RAE1 ribonucleic acid export 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPATA5L1 spermatogenesis associated 5-like 1
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WARS tryptophanyl-tRNA synthetase
ZIC1 Zic family member 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
ATPIF1 ATPase inhibitory factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCND1 cyclin D1
CCNG1 cyclin G1
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD81 CD81 molecule
CLDN3 claudin 3
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
ELOVL5 ELOVL fatty acid elongase 5
ESR1 estrogen receptor 1
FBP1 fructose-1,6-bisphosphatase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GATA3 GATA binding protein 3
GDE1 glycerophosphodiester phosphodiesterase 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HSPA8 heat shock 70kDa protein 8
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
KIAA0101 KIAA0101
KIAA1324 KIAA1324
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
MAGED2 melanoma antigen family D2
MGP matrix Gla protein
MPC2 mitochondrial pyruvate carrier 2
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME3 NME/NM23 nucleoside diphosphate kinase 3
NPY1R neuropeptide Y receptor Y1
NUP210 nucleoporin 210kDa
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCCB propionyl CoA carboxylase, beta polypeptide
PNMAL1 paraneoplastic Ma antigen family-like 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSENEN presenilin enhancer gamma secretase subunit
RET ret proto-oncogene
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSRP1 arginine/serine-rich protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
STMN1 stathmin 1
SYNGR2 synaptogyrin 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM135 transmembrane protein 135
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase