BRD-A11087911_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A11087911_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BTG1 B-cell translocation gene 1, anti-proliferative
CALCA calcitonin-related polypeptide alpha
CEMIP cell migration inducing protein, hyaluronan binding
COG2 component of oligomeric golgi complex 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK9 dedicator of cytokinesis 9
E2F2 E2F transcription factor 2
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS1 growth arrest-specific 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
ITGA6 integrin, alpha 6
LEFTY1 left-right determination factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LIPG lipase, endothelial
MAN2A1 mannosidase, alpha, class 2A, member 1
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
NT5E 5'-nucleotidase, ecto (CD73)
NUTF2 nuclear transport factor 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCQ protein kinase C, theta
PSAP prosaposin
PSPH phosphoserine phosphatase
PTCH1 patched 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STXBP1 syntaxin binding protein 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM9SF3 transmembrane 9 superfamily member 3
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRL2 adhesion G protein-coupled receptor L2
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C7 complement component 7
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CD200 CD200 molecule
CD24 CD24 molecule
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
COCH cochlin
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CSTA cystatin A (stefin A)
CX3CL1 chemokine (C-X3-C motif) ligand 1
DCLK1 doublecortin-like kinase 1
DCN decorin
DPYD dihydropyrimidine dehydrogenase
DST dystonin
EFHD1 EF-hand domain family, member D1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
FGF13 fibroblast growth factor 13
GABPB1 GA binding protein transcription factor, beta subunit 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KRT15 keratin 15, type I
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM5 minichromosome maintenance complex component 5
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLPH melanophilin
N4BP2L1 NEDD4 binding protein 2-like 1
NKX3-1 NK3 homeobox 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRC1 protein regulator of cytokinesis 1
PRR15L proline rich 15-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
RPS11 ribosomal protein S11
SASH1 SAM and SH3 domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX10 sorting nexin 10
SPDEF SAM pointed domain containing ETS transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYNGR1 synaptogyrin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TCF4 transcription factor 4
TGFB3 transforming growth factor, beta 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
VAV3 vav 3 guanine nucleotide exchange factor
WIF1 WNT inhibitory factor 1
ZNF91 zinc finger protein 91