BRD-A11087911_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-A11087911_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOD apolipoprotein D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALD1 caldesmon 1
CDK6 cyclin-dependent kinase 6
CLNS1A chloride channel, nucleotide-sensitive, 1A
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
EAPP E2F-associated phosphoprotein
ELF1 E74-like factor 1 (ets domain transcription factor)
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPC3 glypican 3
GPX2 glutathione peroxidase 2
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HIST2H2BE histone cluster 2, H2be
IGFBP3 insulin-like growth factor binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
INHBA inhibin, beta A
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1C1 mannosidase, alpha, class 1C, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NKX3-1 NK3 homeobox 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PEBP1 phosphatidylethanolamine binding protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PRDM2 PR domain containing 2, with ZNF domain
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SRPX sushi-repeat containing protein, X-linked
STAT1 signal transducer and activator of transcription 1, 91kDa
TBCB tubulin folding cofactor B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM34 translocase of outer mitochondrial membrane 34
TRD T cell receptor delta locus
TSKU tsukushi, small leucine rich proteoglycan
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
APOLD1 apolipoprotein L domain containing 1
ARG2 arginase 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L1 BCL2-like 1
CANT1 calcium activated nucleotidase 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
DAXX death-domain associated protein
DCHS1 dachsous cadherin-related 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHL2 four and a half LIM domains 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GDF15 growth differentiation factor 15
GPM6A glycoprotein M6A
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HMG20B high mobility group 20B
HOXB7 homeobox B7
IER3 immediate early response 3
ISOC1 isochorismatase domain containing 1
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LY6E lymphocyte antigen 6 complex, locus E
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MPPED2 metallophosphoesterase domain containing 2
MSLN mesothelin
MUC1 mucin 1, cell surface associated
MYBPC1 myosin binding protein C, slow type
MYOF myoferlin
NPTX2 neuronal pentraxin II
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLEKHA5 pleckstrin homology domain containing, family A member 5
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKD3 protein kinase D3
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RFTN1 raftlin, lipid raft linker 1
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNCAIP synuclein, alpha interacting protein
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SYT1 synaptotagmin I
TDO2 tryptophan 2,3-dioxygenase
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TYMS thymidylate synthetase
WT1 Wilms tumor 1
ZNF83 zinc finger protein 83