BRD-A11007541_B4313_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-A11007541_B4313_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42SE1 CDC42 small effector 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L2 chitinase 3-like 2
CLTB clathrin, light chain B
CRY1 cryptochrome circadian clock 1
CRYAB crystallin, alpha B
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FGF2 fibroblast growth factor 2 (basic)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GRN granulin
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IL6R interleukin 6 receptor
INHBA inhibin, beta A
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LITAF lipopolysaccharide-induced TNF factor
LMNA lamin A/C
LRP10 low density lipoprotein receptor-related protein 10
LRRC15 leucine rich repeat containing 15
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS23 protease, serine, 23
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND1 Rho family GTPase 1
RNMT RNA (guanine-7-) methyltransferase
RPL38 ribosomal protein L38
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STK17A serine/threonine kinase 17a
TAGLN2 transgelin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
AKAP1 A kinase (PRKA) anchor protein 1
AKAP11 A kinase (PRKA) anchor protein 11
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
B3GNT1
CA12 carbonic anhydrase XII
CDK1 cyclin-dependent kinase 1
CFB complement factor B
CPOX coproporphyrinogen oxidase
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDHD2 DDHD domain containing 2
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DUT deoxyuridine triphosphatase
EREG epiregulin
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
FGFR3 fibroblast growth factor receptor 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HELLS helicase, lymphoid-specific
HP haptoglobin
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
OXCT1 3-oxoacid CoA transferase 1
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PDZRN3 PDZ domain containing ring finger 3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35E2B solute carrier family 35, member E2B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF1 serine/arginine-rich splicing factor 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa