BRD-A11007541_B4313_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-A11007541_B4313_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHI1 Abelson helper integration site 1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C6ORF48 chromosome 6 open reading frame 48
CACYBP calcyclin binding protein
CBX4 chromobox homolog 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD1 chromodomain helicase DNA binding protein 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ERBB2IP erbb2 interacting protein
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FADS1 fatty acid desaturase 1
FAM46A family with sequence similarity 46, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXD1 forkhead box D1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INSIG1 insulin induced gene 1
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM7A lysine (K)-specific demethylase 7A
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED13 mediator complex subunit 13
MOK MOK protein kinase
MSX1 msh homeobox 1
MXD1 MAX dimerization protein 1
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NIPBL Nipped-B homolog (Drosophila)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH2B3 SH2B adaptor protein 3
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMOX spermine oxidase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TBPL1 TBP-like 1
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
UPP1 uridine phosphorylase 1
WSB1 WD repeat and SOCS box containing 1
ZBTB11 zinc finger and BTB domain containing 11
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF292 zinc finger protein 292
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADCY9 adenylate cyclase 9
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ALB albumin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASB13 ankyrin repeat and SOCS box containing 13
ATF5 activating transcription factor 5
B3GNT1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C3 complement component 3
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD24 CD24 molecule
CDC20 cell division cycle 20
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSC cathepsin C
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS1 dehydrogenase/reductase (SDR family) member 1
ELOVL6 ELOVL fatty acid elongase 6
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
ESR1 estrogen receptor 1
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FAP fibroblast activation protein, alpha
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBN2 fibrillin 2
FLNB filamin B, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFRA1 GDNF family receptor alpha 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IGFBP3 insulin-like growth factor binding protein 3
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KRT7 keratin 7, type II
LAMA5 laminin, alpha 5
LAMP5 lysosomal-associated membrane protein family, member 5
LDOC1 leucine zipper, down-regulated in cancer 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAGEF1 melanoma antigen family F1
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MINA MYC induced nuclear antigen
MLEC malectin
MUC1 mucin 1, cell surface associated
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
NUAK1 NUAK family, SNF1-like kinase, 1
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIN2 Ras and Rab interactor 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC35E2B solute carrier family 35, member E2B
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPAG16 sperm associated antigen 16
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TMEM243 transmembrane protein 243, mitochondrial
TMEM50B transmembrane protein 50B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
WRB tryptophan rich basic protein
ZNF185 zinc finger protein 185 (LIM domain)