BRD-A10977446_carvedilol_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-A10977446_carvedilol_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
AHCYL1 adenosylhomocysteinase-like 1
AREG amphiregulin
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
C14ORF1 chromosome 14 open reading frame 1
CD24 CD24 molecule
CD9 CD9 molecule
CETN2 centrin, EF-hand protein, 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
G6PD glucose-6-phosphate dehydrogenase
GREB1 growth regulation by estrogen in breast cancer 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLAU plasminogen activator, urokinase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
TMEM97 transmembrane protein 97

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1R complement component 1, r subcomponent
CDK1 cyclin-dependent kinase 1
CRYAB crystallin, alpha B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
KIF2C kinesin family member 2C
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLK1 polo-like kinase 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRM2 ribonucleotide reductase M2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLPI secretory leukocyte peptidase inhibitor
SNX10 sorting nexin 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated