BRD-A10977446_CARVEDILOL_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

24 genes differentially expressed following the BRD-A10977446_CARVEDILOL_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LTF lactotransferrin
PPIC peptidylprolyl isomerase C (cyclophilin C)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
WAC WW domain containing adaptor with coiled-coil

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
CAST calpastatin
CPE carboxypeptidase E
CYR61 cysteine-rich, angiogenic inducer, 61
HSPA1A heat shock 70kDa protein 1A
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MSLN mesothelin
PLK1 polo-like kinase 1
PODXL podocalyxin-like
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMS spermine synthase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
THBS1 thrombospondin 1
VCAN versican