BRD-A10715913_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-A10715913_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMD1 adenosylmethionine decarboxylase 1
ANKRD28 ankyrin repeat domain 28
ANXA3 annexin A3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARL8B ADP-ribosylation factor-like 8B
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COPA coatomer protein complex, subunit alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREG1 cellular repressor of E1A-stimulated genes 1
CTSB cathepsin B
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EMX2 empty spiracles homeobox 2
FOLR1 folate receptor 1 (adult)
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GOLIM4 golgi integral membrane protein 4
HEG1 heart development protein with EGF-like domains 1
HP haptoglobin
HSPA4L heat shock 70kDa protein 4-like
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL13RA1 interleukin 13 receptor, alpha 1
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5A lysine (K)-specific demethylase 5A
KIF1B kinesin family member 1B
KIF20A kinesin family member 20A
KIF5B kinesin family member 5B
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSRB2 methionine sulfoxide reductase B2
MYO6 myosin VI
NNMT nicotinamide N-methyltransferase
NNT nicotinamide nucleotide transhydrogenase
NUPR1 nuclear protein, transcriptional regulator, 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM5 PDZ and LIM domain 5
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STAT1 signal transducer and activator of transcription 1, 91kDa
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
UBL3 ubiquitin-like 3
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAMP7 vesicle-associated membrane protein 7
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
ACAN aggrecan
ACD adrenocortical dysplasia homolog (mouse)
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ANGPT2 angiopoietin 2
ANXA1 annexin A1
APOD apolipoprotein D
ATM ATM serine/threonine kinase
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL6 B-cell CLL/lymphoma 6
C1ORF106 chromosome 1 open reading frame 106
CAV1 caveolin 1, caveolae protein, 22kDa
CD200 CD200 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
COL21A1 collagen, type XXI, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CSNK1A1 casein kinase 1, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FBXW12 F-box and WD repeat domain containing 12
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GPM6B glycoprotein M6B
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HAPLN1 hyaluronan and proteoglycan link protein 1
IER5 immediate early response 5
IGF1 insulin-like growth factor 1 (somatomedin C)
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
ISYNA1 inositol-3-phosphate synthase 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
LDB2 LIM domain binding 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFP lipoma HMGIC fusion partner
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NPIPB3 nuclear pore complex interacting protein family, member B3
OGN osteoglycin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4C phosphodiesterase 4C, cAMP-specific
PGF placental growth factor
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
SCG3 secretogranin III
SELE selectin E
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC35E1 solute carrier family 35, member E1
SRPX sushi-repeat containing protein, X-linked
SSPN sarcospan
TFPI2 tissue factor pathway inhibitor 2
TOB1 transducer of ERBB2, 1
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
USP34 ubiquitin specific peptidase 34
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF160 zinc finger protein 160
ZNF423 zinc finger protein 423
ZNF611 zinc finger protein 611
ZNF721 zinc finger protein 721